A substudy of the PLAPCI trial comparing Phospholipase A2 release with tissue characteristics as determined by invasive ultrasound and infrared imaging of the heart arteries in patients with coronary artery disease undergoing coronary artery stenting.

The release of Phospholipase A2 biomarkers during percutaneous coronary intervention in patients with significant coronary artery disease and the relationship of released biomarkers with optical coherence tomography and intravascular ultrasound tissue characterisation.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000869976

Acronym

PLAPCI imaging substudy

Enrollment

Registered

2011-08-16

Start date

2011-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to assess the effect of elective coronary stenting procedures on the release of enzymes (PLA2) found in the wall of the coronary artery, and how this release relates to the characteristics of the artery wall as assessed by novel invasive imaging tools

Interventions

Invasive imaging of the coronary arteries prior to and after elective coronary stenting with optical coherence tomography and intravascular ultrasound. Imaging will take place on two occasions approximately 30 minutes apart and will take 15-20minutes to perform on each occasion.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

Patients undergoing elective percutaneous coronary intervention age 18 to 85 years

Exclusion criteria

Myocardial Ischaemic event <14 days prior to participation Change in HMG Co-A reductase inhibitor (statin) in the last 30 days Current acute or chronic inflammatory condition Coronary vessels unsuitable for invasive imaging, including planned left main stenting

Outcome results