The efficacy of low-power laser in amelioration of pain , dysesthesia and Lhermitte’s sign in multiple sclerosis patients

The efficacy of low-power laser in addition to Gabapentin, compared to treatment with Gabapentin alone in the amelioration of pain and improvement of quality of life in multiple sclerosis patients

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000841976

Enrollment

Registered

2011-08-10

Start date

2011-07-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Pain and sensory deficit is one of the main complaints of MS patients. Although there are some medical therapy for pain relief but they are associated with some side effects too; In the other hand low power laser is a secure and effective modality in relieving pain and dysesthesia from 2002 when FDA approve it.

Interventions

different Probe that will be used on cervical and thoracic spinal culomn one after another: 1) MLO1K: Helium, Neon, Argon Amplitude: 500-670 nm Duration: 1-5 min Power: 20 j/cm2 2) KLO6: Helium, Neon Amplitude: 500-670 nm Duration: 10-40 second Power: 172 j/cm2 3) KLO3: Helium, Neon Amplitude: 500-670 nm Duration: 10-30 second Power: 10/5 j/cm2 4) RED Amplitude: 500-660 nm Power: 10/9 j/cm2 Duration of laser therapy in each session: 10-15 min Location: cervical and thoracic spinal cord Frequency of sessions: once daily for 10 days(5 continuous days, 2 days rest, and another 5 continuous days) Laser and Gabapentin capsule (300mg/day) will be administered simultaneously.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Healthy volunteers

Inclusion criteria

Definitive diagnosed MS with MC-donald 2010 criteria Cervical pain, Lhermitte's sign, painful dysesthesia in upper limbs or pain in lumbar and pelvic regions and dysesthesia in shoulder girdle.

Exclusion criteria

MS attack or need for corticosteroid pulses. Addiction or using drugs simultaneous with therapy. Simultaneous using of regular powerful anti-inflammatory drugs Other causes except than spinal cord plaques produce pain, dysesthesia and Lhermitte's sign.

Outcome results