None listed
Conditions
Brief summary
A number of observational studies have demonstrated that snoring in pregnancy is associated with the development of pregnancy hypertension and its associated pregnancy complications. It is known that upper airway dimensions narrow during pregnancy and this will lead to increased airway closure resulting in snoring. Snoring is associated with obstructive sleep apnoea (OSA) which is a condition strongly linked with the development of systemic hypertension. OSA related hypertension improves on treamtent with continuous positive airway pressure (CPAP). One small trial (16 patients) suggests that CPAP may be of benefit in snoring women with pregnancy hypertension. This is a large randomised trial to assess whether CPAP treatment can improve blood pressure control and therefore pregnancy outcomes in hypertensive pregnant women who snore.
Interventions
Randomised treatment with CPAP. CPAP will be delivered primarily via a nasal mask, although other mask types will be tried as needed to ensure a comfortable fit and good interface with the patient. CPAP pressure will be provided using a variable pressure S8 Autoset device (ResMed) set to deliver a pressure between 4-16 cmH2O. Participants will be encouraged to wear the CPAP every time they sleep and use of CPAP will commence at randomisation and continue through to delivery day.
CPAP will be com
Randomised treatment with CPAP. CPAP will be delivered primarily via a nasal mask, although other mask types will be tried as needed to ensure a comfortable fit and good interface with the patient. CPAP pressure will be provided using a variable pressure S8 Autoset device (ResMed) set to deliver a pressure between 4-16 cmH2O. Participants will be encouraged to wear the CPAP every time they sleep and use of CPAP will commence at randomisation and continue through to delivery day. CPAP will be commensed as soon as possible after randomisation. The exact day they start CPAP will vary from patient to patient but will be within 2 weeks of randomisation.
Sponsors
Health Research Council of New Zealand
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Women presenting with early hypertension in pregancy (before 20 weeks gestation) and a history of snoring.
Exclusion criteria
Known secondary hypertension.
Outcome results
None listed