None listed
Conditions
Brief summary
To determine whether a commonly used medication for blood pressure (felodipine) could be a cause of interactions with other medication that can lead to adverse effects.
Interventions
Simultaenous administration of single doses of six drugs (caffeine 100mg, losartan 25mg, omperazole 20mg, dextromethorphan 30mg, midazolam 2mg, digoxin 250mcg) on two occasions a week apart. These drugs will be administered orally (as tablets - caffeine, losartan, omeprazole, digoxin; as solutions diluted in water - midazolam, dextromethorphan) with water. Administration of felodipine extended-release 10mg daily, commencing the day after the first administration of the six drug panel and continu
Simultaenous administration of single doses of six drugs (caffeine 100mg, losartan 25mg, omperazole 20mg, dextromethorphan 30mg, midazolam 2mg, digoxin 250mcg) on two occasions a week apart. These drugs will be administered orally (as tablets - caffeine, losartan, omeprazole, digoxin; as solutions diluted in water - midazolam, dextromethorphan) with water. Administration of felodipine extended-release 10mg daily, commencing the day after the first administration of the six drug panel and continuing until the time of second administration of the panel. The felodipine will be given as tablets with water.
Sponsors
Flinders University
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy Aged 18-50
Exclusion criteria
taking medications significant health conditions unable to comply with study requirements
Outcome results
None listed