None listed
Conditions
Brief summary
Analysis of hemodialysed patients immune response to Anti Hepatitis B vaccination performing a dialysis treatment with a high capacity adsorbent polymethylmetacrylate dialyzer
Interventions
Analysis of the effectiveness in practice of the use of polymethylmethacrylate membrane dialyzers as adjuvant in the treatment of dialysis patients in the course of anti - Hepatitis B vaccination.
Arm1: patients on maintainance thrice-weekly dialysis resulting non responder to anti-Hepatitis B vaccination in accordance with Center for Desease Control (CDC) and prevention criteria and discontinuing their actual dialysis membrane switching to a polymethylmethacrylate membrane with high pore size
Analysis of the effectiveness in practice of the use of polymethylmethacrylate membrane dialyzers as adjuvant in the treatment of dialysis patients in the course of anti - Hepatitis B vaccination. Arm1: patients on maintainance thrice-weekly dialysis resulting non responder to anti-Hepatitis B vaccination in accordance with Center for Desease Control (CDC) and prevention criteria and discontinuing their actual dialysis membrane switching to a polymethylmethacrylate membrane with high pore size and a enhanced absorptive capacity for at least four month, at the third month receiving a regular vaccine booster dose. Arm2: patients on maintainance thrice-weekly dialysis resulting non responder to anti-Hepatitis B vaccine with CDC criteria not using any kind of polymetylmethacrilate membrane dialyzers, at the third month receiving a regular vaccine booster dose. We intend to observe if there is any difference between the two groups in term of response to the vaccine booster dose.
Sponsors
USL 8 Arezzo P.O. Ospedale S. Donato di Arezzo
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
End Stage Renal desease patients on mainteinance thrice-weekly dialysis treatment who had been defined as non-responder to Hepatitis B vaccination according to CDC criteria
Exclusion criteria
End Stage Renal desease patients on mainteinance thrice-weekly dialysis treatment who had been defined as non responder to Hepatitis B vaccination according to CDC criteria already using any kind of polymethylmethacrylate membrane dialyzers at the initial time of observation
Outcome results
None listed