None listed
Conditions
Brief summary
All women with PCOS who fullfiled the criteria and agreed to participate in the study will be randomized (by computer-generated randomization) into two groups. Group 1 will be treated with Vitamin D 50000 units orally for the first week followed by 1000 units daily for three months starting from the first day of a spontaneous cycle or progestin withdrawal and 100 mg clomiphene citrate for five days from day three of the menstrual period. Group 2 will be treated with placebo for three months starting from the first day of a spontaneous cycle or progestin withdrawal and 100 mg clomiphene citrate for five days from day three of menses. Ovulation is confirmed by midluteal serum P values of > 8.0 ng / ml.
Interventions
All women with PCOS who fullfiled the criteria and agreed to participate in the study will be randomized (by computer-generated randomization) into two groups. Group 1 will be treated with Vitamin D 50000 units once orally for the first week followed by 1000 units orally daily for three months starting from the first day of a spontaneous cycle or progestin withdrawal and 100 mg clomiphene citrate daily orally for five days from day three of the menstrual period. Group 2 will be treated with plac
All women with PCOS who fullfiled the criteria and agreed to participate in the study will be randomized (by computer-generated randomization) into two groups. Group 1 will be treated with Vitamin D 50000 units once orally for the first week followed by 1000 units orally daily for three months starting from the first day of a spontaneous cycle or progestin withdrawal and 100 mg clomiphene citrate daily orally for five days from day three of the menstrual period. Group 2 will be treated with placebo once orally in the first week followed by placebo daily orally for three months starting from the first day of a spontaneous cycle or progestin withdrawal and 100 mg clomiphene citrate daily orally for five days from day three of menses. Ovulation is confirmed by midluteal serum P values of > 8.0 ng / ml.
Sponsors
King Abdulaziz University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
Women attending the infertility clinics at King Abdulaziz University Hospital. PCOS is being defined as any women with two out of three criteria 1). Oligo- or anovulation; 2). Clinical and/or biochemical signs of hyperandrogenism; and 3). Polycystic ovaries and exclusion of other etiologies (congenital adrenal hyperplasia, androgen-secreting tumors, and Cushing's syndrome)
Exclusion criteria
Refusal to participate in the study Male factor infertility Fallopian tubal disease
Outcome results
None listed