Comparison between intraarticular dexmedetomidine and morphine for postoperative analgesia after arthroscopic meniscal surgery

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000772943

Enrollment

Registered

2011-07-22

Start date

2011-04-09

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This randomized double-blind study was designed to determine the analgesic effects of intra-articular dexmedetomidine and to compare it with those of morphine in patients undergoing arthroscopic knee surgery.

Interventions

Arm 1: Intra-articular dexmedetomidine 1 mcg/kg (in 20 ml saline) before wound closure once Arm 2: Intra-articular morphine 30 mcg/kg (in 20 ml saline) before wound closure once

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

- American Society of Anesthesiologists’ physical class I or II - Arthroscopic meniscal surgery under general anaesthesia - Elective surgery

Exclusion criteria

- Regional anaesthesia - History of opioids or sedative agents use on regular basis for more than a week prior to surgery - renal impairment (serum creatinine > 200 mcg/ml)

Outcome results