Randomized clinical trial of operation and non-operation for small liver cancer

A randomized clinical trial to compare overall survival and disease-free survival in small liver cancer patients treated with surgery versus transcatheter arterial chemoembolization plus radiofrequency ablation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000770965

Enrollment

200

Registered

2011-07-22

Start date

2006-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of our study is to compare the preferences of transcatheter arterial chemoembolization (TACE) plus percutaneous radiofrequency ablative therapy (RFA) and liver resection in the treatment of early small HCC. We suppose that TACE plus RFA can have equal or better effect.

Interventions

Liver resection was carried out under general anesthesia through a right subcostal incision. The surgery was performed to resect the tumor with a resection margin of at least 1 cm to tumor margin. Pringle’s maneuver was routinely used with a clamp/unclamp time of 15 minutes/5 minutes.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

1.clinically diagnose as primary liver cancer 2.no anticancer treatment 3.single tumor with diametre<=5cm,or multiple focus with diametre<=3cm and number<=3 4.the tumor can be cured by surgery or non-operational treatment(TACE+RFA,OR TACE+PEIT) 5.liver function is Child A or B

Exclusion criteria

1.blood vessel or adjacent organs invasion 2.lymphatic or systemic metastasis 3.coagulation dysfunction

Outcome results