None listed
Conditions
Brief summary
Stroke is a leading cause of adult disability. In this project a team of clinicians and scientists will evaluate the benefits of a new process for prescribing rehabilitation after stroke, called “Targeted Rehabilitation, Improved Outcomes” (TRIO). The project will implement an algorithm for determining individual patients’ potential for recovering hand and arm movement, and setting appropriate rehabilitation goals. This algorithm uses a combination of simple bedside tests, neurophysiology and neuroimaging, to measure the amount of damage to key pathways in the brain. The research team will evaluate the benefits for patient outcomes of using this algorithm as part of rehabilitation prescription.
Interventions
The prognosis group will have a number of measures made, to predict their potential for recovering hand and arm function after stroke. These measures include simple bedside tests of movement, neurophysiological and neuroimaging measures. The simple beside measures of hand and arm strength will be made within 1 week of stroke. The neurophysiological measures involve using transcranial magnetic stimulation to test the pathways from the movement area of the brain to the weak arm muscles. These mea
The prognosis group will have a number of measures made, to predict their potential for recovering hand and arm function after stroke. These measures include simple bedside tests of movement, neurophysiological and neuroimaging measures. The simple beside measures of hand and arm strength will be made within 1 week of stroke. The neurophysiological measures involve using transcranial magnetic stimulation to test the pathways from the movement area of the brain to the weak arm muscles. These measures will be made within 2 weeks of stroke. The neuroimaging measures involve a short magnetic resonance imaging (MRI) scan, which will take place within 2 weeks of stroke. This information will be provided to therapy teams and to the patients, to guide rehabilitation planning and goal-setting. Standard rehabilitation therapies will be provided, though the intensity and duration of these therapies may be modified by prognosis information.
Sponsors
University of Auckland
Study design
Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Diagnosis
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Over 18 years of age Unilateral upper limb weakness as a result of stroke
Exclusion criteria
Cerebellar stroke Severe cognitive or communication impairment that precludes informed consent Contraindications to magnetic resonance imaging or transcranial magnetic stimulation
Outcome results
None listed