A randomized controlled trial of three new treatments for anorexia nervosa in adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000725965

Acronym

SWAN - Strong Without Anorexia Nervosa Study

Enrollment

120

Registered

2011-07-12

Start date

2010-05-01

Completion date

2013-12-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The Strong Without Anorexia Nervosa (SWAN) Study is evaluating three psychological treatments for anorexia nervosa and atypical anorexia nervosa in adults. It is funded by the National Health and Medical Research Council of Australia and will be one of the largest study of its kind worldwide. Men and women aged 17 years and older with anorexia nervosa or atypical anorexia nervosa, who are able to attend appointments in Perth, Adelaide or Sydney, are eligible to take part. Participation is free and the Study is running from 2010 to 2015. It is hoped that 120 individuals will participate across the three states

Interventions

Participants will receive between 25 and 40 outpatient, individual treatment sessions with a registered Psychologist, each lasting 50 minutes duration. The number of sessions will be determined by the participant's starting Body Mass Index. Sessions will be spaced over a 10 month period. Participants will be randomly allocated to one of three psychological treatments: Maudsley Model Anorexia Nervosa Treatment for Adults (MANTRA), Enhanced Cognitive Behaviour Therapy (CBT-E), or Specific Supportive Clinical Management (SSCM). All are based on established treatment manuals and guidelines, and all psychologists have been trained in the treatments by the treatment developers. MANTRA and CBT-E are hypothesised to result in greater improvements in symptomatology. MANTRA uses a motivation-focused approach and incorporates work on thinking styles, social and emotional functioning, pro-anorexic beliefs, and interpersonal relationships. CBT-E focuses on the thoughts and beliefs that maintain the eating disorder, and incorporates mood regulation work.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

17 Years to No maximum

Healthy volunteers

Inclusion criteria

aged at least 17 years, and fulfil our research criteria for AN phenotype which are: meeting criteria A and B of DSM-IV for AN (i.e., refusal to maintain normal body weight and intense fear of gaining weight) and BMI<18.5 kg/m2.

Exclusion criteria

Current manic episode or psychosis; current alcohol or substance abuse or dependence; significant current medical or neurological illness (including seizure disorder) which impacts on their weight, with the exception of nutrition-related alterations; pregnancy, BMI less than 14kg/m2 , or any other circumstances (e.g., not being available for the full course of treatment) that make it inappropriate for them to enter the trial.

Outcome results