Comparison of minimally invasive cardiac output monitors in the detection of hypovolaemia in awake volunteers.

Awake volunteer study of controlled hypovolaemia investigating the ability of minimially invasive cardiac output monitors (LiDCO Rapid, FloTRAC, Oesophageal doppler and USCOM) in detecting known blood loss.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000707965

Enrollment

Registered

2011-07-08

Start date

2011-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

this study seeks to determine if minimially invasive monitors can detect blood loss in awake patients. Our hypothesis is that the monitors will be able to detect a known blood loss of 10% of estimated blood volume. We will test this by bleeding volunteers a known amount of blood and then looking to see if the monitors detect this blood loss.

Interventions

Participants will be monitored with an arterial line (connected to LiDCO rapid and FloTrac monitors), oesophageal doppler and suprasternal doppler. Participants will be venesected incrementally to a 20% blood loss. The venesection will be a once only event lasting over approximately 2 hours.. FloTrac and LiDCO are arterial pulse wave contour analysis devices that derive information about the cardiovascular system from the nature of the observered arterial waveform. Oesophageal doppler uses ultrasound to assess blood flow in the descending aorta and interperets this flow based on the patients age and body habitus. Suprasternal doppler (USCOM) also uses doppler to assess flow but from the suprasternal notch rather than from the oesophagus.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Healthy adult, not taking cardiovascularly active medication

Exclusion criteria

Cardiovascular medications abnormal cardiovascular history or examination

Outcome results