Dietary fat, airway inflammation and bronchodilator response in asthma - Study 1

A randomised controlled, 3-way crossover trial, to examine the effects of a high fat or carbohydrate meal on bronchodilation in adults with stable asthma.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000692932

Acronym

FAB Study - Study 1

Enrollment

Registered

2011-07-07

Start date

2012-11-02

Completion date

2014-07-28

Last updated

2020-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this project is to examine whether impaired bronchodilator recovery in asthma is due to: 1. reduced bronchodilation and/or 2. reduced bronchoprotection. This will be explored in 2 studies. Participants can participate in 1 or both of these studies. Study 1 is described below. Study 1. Effects of macronutrients on bronchodilation At baseline, participants will consume the study meal (fat, carbohydrate or water), then their lung function will be assessed. They then will be administered with a short acting B2-agonist (salbutamol 400ug). Lung function measurements will then be repeated hourly, for the next 6 hours.

Interventions

At each visit, participants will consume a study meal. The order in which the study meals will be consumed will be randomly allocated. There will be a washout period of 1 week between visits. The study meals are as follows: 1. Fat: 100mL double cream, providing 45g (96%) fat, 29g saturated fat, 1740kJ. 2. Carbohydrate: 104g high energy drink, providing 100% carbohydrate, 1740kJ. 3. Control: 100mL water Participants will be asked to consume each meal within a 15 minute timeframe. On arrival baseline lung function will be performed followed by the administration of a short acting B2-agonist (salbutamol 400ug, inhaled via a spacer). The participant will then consume the study meal. Participants who complete Study 1 may also participate in Study 2.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Stable asthma, non smokers

Exclusion criteria

BMI > 35, history of coronary heart disease, diabetes or currently taking lipid lowering drugs or oral corticosteroids.

Outcome results