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The effect of diet and portion size on oral fatty acid sensitivity

In overweight and obese subjects, will following a low-fat diet, or following a portion control diet, have an effect on oral fatty acid sensitivity.

Status
Completed
Phases
Early Phase 1
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12611000679987
Enrollment
110
Registered
2011-07-05
Start date
2011-04-28
Completion date
2012-11-01
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of this study is to investigate the effect of diet on people's ability to detect fatty acids in the oral cavity.

Interventions

This group will follow a low-fat diet (25% total dietary fat from energy) for 6 weeks. The low-fat diet consists of subjects consuming 5 serves of vegetables per day, 2 serves of fruit per day, 3 serves of low-fat dairy per day, a maximum of 5 serves of carbohydrates (rice, pasta, bread etc) per day and a maximum of 3 serves of fats (butter oil, margarine etc) per day. Subjects are also given a list of foods to try and avoid, including fatty snacks like chips, biscuits cakes etc. Subjects will u

This group will follow a low-fat diet (25% total dietary fat from energy) for 6 weeks. The low-fat diet consists of subjects consuming 5 serves of vegetables per day, 2 serves of fruit per day, 3 serves of low-fat dairy per day, a maximum of 5 serves of carbohydrates (rice, pasta, bread etc) per day and a maximum of 3 serves of fats (butter oil, margarine etc) per day. Subjects are also given a list of foods to try and avoid, including fatty snacks like chips, biscuits cakes etc. Subjects will undergo a one on one dietary counseling session with the nutritionist where the diet they will be following will be explained to them, and questions they may have will be answered. This counseling session occurs once at the beginning of the study, but a weekly phone call will be made to subjects to give them the opportunity to ask questions throughout the 6 week period.

Sponsors

Associate Professor Russell Keast
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
Yes

Inclusion criteria

Non-smokers, Body Mass Index (BMI) > 20

Exclusion criteria

Smokers, BMI < 20

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026