Zinc supplementation trial before and after routine vitamin A supplementation program and their effects on illness in Indonesian preschool children

The effect of zinc supplementation and its interaction with vitamin A on child immune response and morbidity rate in Indonesian preschool children

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000659909

Enrollment

826

Registered

2011-06-28

Start date

2003-06-06

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This zinc supplementation study aimed to investigate the effect of zinc and vitamin A supplementation on immune responses and Upper Respiratory Tract Infections (URTI), diarrhea and other infections in Indonesian preschool children. The study results showed that zinc supplementation in addition to vitamin A supplementation promoted elimination of vitamin A deficiency and reduced upper respiratory tract infection morbidity. Zinc supplementation increased ex vivo INF gamma production, but vitamin A supplementation had no measurable impact on general immune responses used in the study.

Interventions

10mg elemental zinc in syrup daily for 4 months, i.e. 2 months before routine vitamin A supplementation and 2 months after vitamin A supplementation. Vitamin A supplementation were given as a single dose capsule of 200.000 IU retinol

Study design

Allocation

Randomised controlled trial

Intervention model

Other

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

24 Months to 59 Months

Healthy volunteers

Yes

Inclusion criteria

Age 2-5 years old Live in the study area Generally healthy

Exclusion criteria

Moved to other area Consume supplements <75% of the total supplement days

Outcome results