Administration of pantoprazole and its effects on gastric PH,inflammatory & anti inflammatory factors in critically ill patients.

A Comparative study of bolus & Continuous administration of pantoprazole on gastric PH and its effect on inflammatory & anti inflammatory cytokines(IL1,TNFa vs IL10,EGF) in critically ill patients.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000647932

Enrollment

Registered

2011-06-23

Start date

2010-11-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Cytokines have some roles in stress related mucosal damage (SRMD),some studies mentioned probable anti inflamatory effects of proton pump inhibitors(PPIs). The primary purpose of this study is to find that if PPIs in critically ill patients can reduce inflamatory factors secreted in gastric juice in addition to increase the gastric pH?

Interventions

Arm 1: Critically ill patients with gastric pH below 3,bolus Pantoprazole(80 mg/day,48 hours) Arm 2:Critically ill patients with gastric pH below 3, continuous infusion Pantoprazole(80mg/day,48 hours) Arm3:Critically ill patients with gastric pH below 3,continuous infusion Ranitidin(150mg/day,48hours) pH measure by a pH meter probe and litmus paper

Study design

Allocation

Randomised controlled trial

Primary purpose

Treatment

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

Inclusion Criteria : 1-Age>18 2-Clinical need for a nasogastric tube 3-Expectation of 48 hrs of “nothing by mouth” status 4-Baseline gastric pH <3.5 5-High risk patients for stress ulcer(one of these risk factors) patients with Coagulopathy disorders. Ventilator dependant patients, shock, Respiratory failure, trauma

Exclusion criteria

1-History of peptic ulcer disease 2-Patients with zollinger Ellison 3-Recipients of H2 blockers & NSAIDS 4-Tube feeding 5-Creatinine>2 or Creatinine > %25 increase in base line 6-Abnormal LFT (3 times>base line) 7- Renal failure

Outcome results