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Keeping parturient in the left lateral position after spinal anesthesia with plain levobupivacaine at cesarean section reduces hypotension

Keeping the parturients in the left lateral position for few minutes obtains dense anesthesia for the surgical site (below T10), and delayed placing to the supine position provides less dense anesthesia up to T5 to relieve the visceral part of surgical pain

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12611000608965
Enrollment
60
Registered
2011-06-14
Start date
2010-11-15
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Hypotension during spinal anesthesia is one of the main concerns in cesarean delivery. We hypothesized that keeping the parturients in the left lateral position for few minutes obtains dense anesthesia for the surgical site (below T10), and delayed placing to the supine position provides less dense anesthesia up to T5 to relieve the visceral part of surgical pain. Less dense anesthesia in the upper thoracic segments results in incomplete sympathetic block and low incidence of hypotension. Method: In this prospective study, 60 parturients undergoing cesarean section were randomized for turning to supine position just after subarachnoid injection of 2.5 mL 0.5% plain levobupivacaine in lateral position or to stay in lateral position for 15 minutes before supine positioning. Loss of pinprick sensation to T6 was accepted as adequate for cesarean section, and surgery proceeded. Characteristics of anesthesia, incidences of hypotension, bradycardia, other adverse events, and ephedrine use were assessed. Results: Compared to the supine group, the parturients kept in lateral position for 15 minutes experienced a marked decrease in the incidence of hypotension (33.3% vs. 83.3%, P<0.001) and adverse events related to hypotension such as nausea and vomiting (16.7% vs. 57.3%, P<0.001). In addition, ephedrine consumption per hypotension case was significantly reduced in the lateral group (5.4 +/- 4.7 mg vs 8.9 +/- 5.8, p<0.001). Conclusion: Keeping parturients in the lateral position for 15 minutes before turning to the supine position in cesarean section can provide a reliable spinal anesthesia with lower incidence and severity of hypotension and nausea/vomiting.

Interventions

Intrathecal injection was performed in the left lateral decubitus position at the L3-4 or L2-3 interspace with a 25-gauge Quincke needle. Following free flow of cerebrospinal fluid, 2.5 mL of 0.5% isobaric levobupivacaine (Chirocaine amp, Abbott, Norway) was administered over 20 seconds without barbotage. After withdrawing the spinal needle, the patients in Group L were kept in the left lateral decubitus position for 15 minutes, after which they were turned to the supine position.

Sponsors

Levent Sahin
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Primary purpose
Prevention

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy, full-term parturients scheduled for elective cesarean section

Exclusion criteria

Hypertension, preeclampsia, hypersensitivity to relevant drugs.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026