Dietary salt and blood vessel function

The effect of a high sodium meal versus a low sodium meal on acute blood vessel function in healthy volunteers: a randomised crossover trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000583943

Enrollment

Registered

2011-06-06

Start date

2011-06-06

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to see whether a salty meal (equivalent to about 3/4 teaspoon of table salt, the same amount found in a ham sandwich or a meal of bacon and eggs) causes levels of sodium (salt) in the blood to rise. We want to know this because high salt meals may have adverse effects on blood vessel function.

Interventions

In a randomised cross-over design, participants will consume a test meal containing 65mmol of sodium or a low salt control meal containing 5mmol sodium on 2 separate study days with a 7 day washout period in between treatments. The test meal will comprise of 100ml of Reduced Salt tomato soup made up with 150mL water with 3.8g of added salt (65mmol NaCl sodium chloride). Participants are asked to consume the test meal over a 5 minute period.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

Male or female aged 18-70 BMI <28kg/m2 and > 18.5 kg/m2 Systolic blood pressure <130mmHg Diastolic blood pressure <90mmHg Weight stable over the past 6 months

Exclusion criteria

-Know metabolic disease such as liver or kidney disease -Treated hypertension -Previous clinical cardiovascular disease -Use of non-steroidal anti-inflammatory drugs, folate supplementation or systemic steroids -Significant weight loss (>5% body weight) in preceding 6 months -Unable to comprehend study protocol

Outcome results