Aged garlic extract for uncontrolled hypertension: a dose-response trial

Aged garlic extract or placebo for uncontrolled hypertension: a randomised double-blind parallel dose response trial

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000581965

Enrollment

Registered

2011-06-06

Start date

2011-08-01

Completion date

2012-03-28

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The study will investigate the efficacy, dose-reponse relationship and acceptability of aged garlic extract for reducing blood pressure in treated but uncontrolled hypertensive general practice patients.

Interventions

Active groups: Aged garlic extract (AGE, Kyolic) orally daily for 12 weeks Group 1: 4 capsules containing 960 mg AGE, 2.4 mg S-AllylCysteine (SAC) Group 2: 2 capsules containing 480 mg AGE, 1.2 mg SAC Group 3: 1 capsule containing 240 mg AGE, 0.6 mg SAC

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

Blood pressure > 140 mm Hg systolic under trial conditions; on established plan of BP medication (one or more classes) for at least 2 months

Exclusion criteria

Unable to give informed consent; unstable medical conditions or serious illness; severe hypertension (> 180 mm Hg); already taking daily garlic supplements

Outcome results