Influence of hemodialysis, hemodiafiltration and peritoneal dialysis on asymmetric dimethylarginine and markers of oxidative stress

Influence of hemodialysis, hemodiafiltration and peritoneal dialysis on asymmetric dimethylarginine and markers of oxidative stress in patients with chronic renal failure.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000577910

Enrollment

Registered

2011-06-06

Start date

2007-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Increased ADMA levels in patients undergoing HD, as compared to PD, may be caused by higher oxidative stress and lower residual renal function in HD. Other factors, such as diabetes and statin therapy, may also be at play. The decrease in ADMA at the end of HD and HDF is comparable. Switching from HD to HDF decreases in 8 weeks the predialysis levels of homocysteine without affecting ADMA.

Interventions

Eight weeks of hemodialysis (HD, low-flux polysulfone membrane) versus eight weeks of on-line predilution hemodiafiltration (HDF, high-flux polysulfone membrane, susbstitution volume 200 mL/min)), duration of both HD and HDF was 4.5 hrs/session 3 times a week. Crossover study, 1 week break in between.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

Patients: persons on maintenance hemodialysis or peritoneal dialysis for at least 3 months. Controls: healthy volunteers withou renal disease.

Exclusion criteria

Unstable clinical condition, infection, malignancy

Outcome results