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Exploring neuroplasticity associated with a combined computerised cognitive training and psychoeducation program in patients with mild cognitive impairment and /or a lifetime history of depression

Exploring neuroplasticity with cognitive training: A healthy brain ageing program for older people with depression or mild cognitive impairment

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12611000570987
Enrollment
112
Registered
2011-06-03
Start date
2009-08-24
Completion date
2012-01-11
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

While many studies have shown that cognitive training in older people is associated with improved cognitive abilities, little is known about the predictors of change, or whether cognitive training is associated with improvements in neurophysiological activity or in ‘real world’ functions such as social relationships. In older individuals ‘at risk’ of cognitive decline, this study therefore aims to determine the neurobiological, clinical and cognitive predictors of ability to benefit from a ‘healthy brain ageing’ cognitive training program. It is expected that those who participate in the treatment will improve in terms of memory functioning.

Interventions

Combined Cognitive Training (CT) and psychoeducation program covering healthy brain ageing. This consists of a two hour group-based (8-10 people) session twice every week for 7 weeks. The psychoeducation sessions are delivered by specialists including clinical neuropsychologists, clinical psychologists, psychogeriatricians, chronobiologists, and experts in diet and exercise. The computer-based cognitive training sessions are facilitated by trained clinical neuropsychologists. The first hour de

Combined Cognitive Training (CT) and psychoeducation program covering healthy brain ageing. This consists of a two hour group-based (8-10 people) session twice every week for 7 weeks. The psychoeducation sessions are delivered by specialists including clinical neuropsychologists, clinical psychologists, psychogeriatricians, chronobiologists, and experts in diet and exercise. The computer-based cognitive training sessions are facilitated by trained clinical neuropsychologists. The first hour delivers information pertinent to healthy ageing including use of cognitive strategies and information on diet and exercise, vascular risk factors, depression, anxiety and sleep. The second hour is a computer based cognitive training program.

Sponsors

Sharon Naismith
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Educational / counselling / training
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
50 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

Cognitive impairment or depression or vascular risk factors

Exclusion criteria

Stroke, transient ischaemic attack (TIA), poor English skills, unable to attend 10-weeks of therapy, neurological disorder, dementia, psychiatric disorder, medical illness with known cognitive effects, prior head injury.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026