None listed
Conditions
Interventions
Mode of Administration will be oral capsule. Part 1- Cohort 1: Rising single dose SCH900931 (Period 1:20mg, Period 2:100mg & Period 3:550mg). The duration of each Period will be 6 days, in between doses for Part 1 will be at least 7 days between Period 1 and Period 2 and at least 21 days between Period 2 and Period 3. Part 2- Cohort 2 & 3 : Rising multiple dose SCH900931 of 2 cohort in a parallel study design (Cohort 2: 150mg & Cohort 3:250mg). For Part 2, dosing will be once daily for 14 consecutive days for subjects in either Cohort 2 or Cohort 3. Subjects will participate only in Part 1 or in one of the 2 cohorts in Part 2. The first part of the study will determine PK dose proportionality by using 3 single doses. The second part of the study will allow for determination of steady-state PK and accumulation ratio by once daily administration for 14 days.
Sponsors
Study design
Eligibility
Inclusion criteria
Healthy Japanese volunteers
Exclusion criteria
History of malignancy, Human Immunodeficiency Virus (HIV), Hepatitis B, Hepatitis C