Validation of the Perth Chest Pain Rule

Validation of protocols for safe early discharge of patients presenting to Emergency Departments with chest pain

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12611000566932

Acronym

MiMiC-2

Enrollment

600

Registered

2011-06-02

Start date

2011-02-14

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Chest pain is a common reason for presentation to an Emergency Department. Current management usually involves observing patients in an Emergency Department over 8-12 hours doing repeated heart tracings and blood tests. A large trial in Perth and overseas studies have suggested that it is possible to shorten this observation period to 2 hours using a panel of blood tests and looking at particular patient characteristics. The aim of this study is to ensure that changing to this method of management will not cause an increase in adverse patient outcomes

Interventions

An additional 10ml of blood will be drawn with the initial blood taken for standard clinical management. An extra venepuncture of 10ml of blood will be drawn at two hours post presentation to the Emergency Department (ED). At some sites, an additional 5ml of blood will be drawn from the sample taken for standard management at 8-12 hour post presentation. Data will be collected using a standardised data collection form. Patients will be managed and discharged as determined by their treating clinician as per their clinical judgement - trial blood sample will not be available to clinicians. Patients will be recuited for six months with the aim for at least 600 patients. Patients wil be telephoned by research nurses at approximately 30 days post ED discharge and asked a series of standard questions regarding their health and investigations since ED discharge. Hospital discharge summaries and results of investigations will be obtained by research staff.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients attending Emergency Departments with chest pain undergoing serial troponin measurement for exclusion of acute coronary syndrome

Exclusion criteria

single troponin measurement, unable to consent, unlikely to be able to obtain follow-up (eg. overseas visitors), pregnant

Outcome results