None listed
Conditions
Brief summary
Objective: Agouti-related peptide is a neuropeptide (132-amino acid) produced in the arcuate nucleus of the hypothalamus. Interleukin-6 (IL-6) is excreting by adiposities, which increased by overweight and obesity. We examined the Impact of exercise conjugated diet and only diet on plasma concentration of agouti-related peptide and Inerleukine-6 in obese and overweight sedentary female collage students Research Methods and Procedures: A total of 30 subjects (age = 21.9 +/- 2.4; weight = 75.6 +/- 5.57; BF = 29.532 +/- 3.18 and BMI = 29.048 +/- 2.216) randomly divided into two experimental and one control groups. The experimental group1 Experienced twelve-day diet (D), the experimental group2 Experienced twelve-day diet (every day) with twelve-day running training (the intensity was 60 to 70 %HRmax for 50 minutes) every other day (AED) and control group remained sedentary with normal diet in this period. Blood samples were collected 24 hours before and after enforced protocol. Body fat percentage of subjects measured using 3 points method. After plasma separation, AGRP levels measured using ELISA method with special Kit. The data was analyzed by K-S, ANOVA and Tukey post-hoc. Results: After doing protocols, the plasma AGRP in the D group increased significantly (p<0.05). Furthermore, resting plasma IL-6 for AED groups reduced significantly (p<0.05). The data indicate that after enforced protocol, AED group was stable on resting plasma AGRP (p>0.05). Discussion: Aerobic Exercise conjugated Diet is better than only diet, because not only it was causing AgRP stable but reduced resting plasma IL-6 as well. Key word: AgRP, IL-6, Obesity, Overweight, Aerobic Exercise, Diet
Interventions
In the present study, we used the weight loss program by doctor Amir and colleagues recommended in 2009.(Amir Rashid lamir, Mahmood Goudarzi, Ali asghar ravasi: effect of gradual and acute weight loss on strength and endurance of well trained wrestlers. World journal of sport sciences, 2009, 2 (4).) Furthermore, we've used this protocol in our study (without any change in it).
Arm 1: Describe the twelve-day only Diet :
We used a weight reduction program (12 days), including researchers propose
In the present study, we used the weight loss program by doctor Amir and colleagues recommended in 2009.(Amir Rashid lamir, Mahmood Goudarzi, Ali asghar ravasi: effect of gradual and acute weight loss on strength and endurance of well trained wrestlers. World journal of sport sciences, 2009, 2 (4).) Furthermore, we've used this protocol in our study (without any change in it). Arm 1: Describe the twelve-day only Diet : We used a weight reduction program (12 days), including researchers proposed twelve-day diet in three 4-day phases, in each phase in the first three day a decrease in nutrition occurred and in the last day a return diet to the previous phase. In the first phase, the subjects decreased 10% of their food (lunch and dinner) and then they returned to their usual eating habits (the food they received before their diet). In the second phase, first they decreased 20% in three day then they returned to 10% reduction on the fourth day. In the third phase, first they decreased 30% % in three day then they returned to 20% reduction on the fourth day. There was no limitation on drinking water and no decrease in breakfast, but the subjects avoided fat in all meals. This weight loss method was extracted from Rashid Lamir's weight loss method. Arm 2: Describe the twelve-day Exercise + Diet: We used a weight reduction program (Described above) along with twelve-day aerobic exercise (exercise intensity was 60 - 70 % HR max for 50 minutes) every other day. Subjects running in the outdoor environment. furthermore, they was supervised by a exercise physiologist.
Sponsors
Ferdowsi University of Mashhad
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 26 Years
Healthy volunteers
No
Inclusion criteria
All female participating were sedentary healthy adult (no disease)and they were overweight and obese.
Exclusion criteria
disease and non-adult, non- sedentaryand also they are not overwieght and obese
Outcome results
None listed