Comparison of magnetic resonance imaging (MRI) and angio computed tomography ( Angio CT) in the characterization of liver lesions in patients with colorectal cancer and possible liver metastases

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000549921

Acronym

nil

Enrollment

160

Registered

2011-05-30

Start date

2011-06-14

Completion date

2013-05-08

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to compare the accuracy of two different diagnostic tests used to examine liver lesions in patients with colorectal cancer. Who is it for? You can join this study if you are aged 18 to 85 years and have colorectal cancer liver metastases for which you are considering surgery. Trial details Participants in this trial will undergo an Angio CT scan and an MRI with Primovist scan. The Angio CT is a very useful standard test which is used to detect lesions within the liver. The test is also very good at showing the relationship of the lesions to the important blood vessels within the liver. However, sometimes this CT picks up lesions which might not be colorectal cancer metastases (a deposit of colorectal cancer within the liver). It is important to know this so that patients are not excluded from surgery because they have too much disease. It is thought that MRI with Primovist may be better at characterising the liver lesions, i.e. MRI with Primovist is better at deciding whether a lesion seen is a colorectal metastases or not. There has never been a study that directly compares Angio CT with MRI with Primovist. This study would aim to make this comparison. It would help us decide which is the better test in different circumstances to assess the liver disease in a patient with colorectal cancer.

Interventions

patients will undergo primovist MRI as part of their work up for presentation with colorectal cancer liver metastases (CRCLM) most patietns will undergo one MRI but may have a second if they need neoadjuvant chemotherapy and then restaging for possible surgery. MRI usually takes about 30 minutes.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

all patients with CRCLM presenting for consideration for resection speak english

Exclusion criteria

Patients under the age of 18; Patients over the age of 85; Poor English and no interpreter present; Renal imparement as this is a contraindication of both Angio CT and some MR contrasts; Patients with permanent cardiac pacemakers or implantable devices which make them ineligable for the MR study.

Outcome results