Can whole body vibration training improve muscle function and bone density in children and adolescents with cerebral palsy?

The effects of whole body vibration training on muscle function and bone density in children and adolescents with cerebral palsy.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000465954

Enrollment

Registered

2011-05-05

Start date

2012-01-25

Completion date

2019-02-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Cerebral palsy (CP) is the most common disability in childhood. CP is characterized by reduced muscle mass, impaired mobility and low bone density. Therefore, one of the major focuses of therapy in CP children is to increase muscle mass and power, thereby increasing mobility, weight bearing and bone health. Unfortunetely, there is a void in therapeutic interventions aimed at increasing muscle mass, muscle function as well as bone mass in CP children. Whole body vibration training (WBVT) has the potential to fill this therapeutic void. WBVT studies in healthy adults and postmenopausal females have been shown to enhance muscle function and bone health. However, it is unclear whether children with CP would benefit from WBVT. By maintaining muscle mass and bone mineral accrual during growth; WBVT can maximize mobility and bone strenght into adult life improving both mobility and quality of life. The proposed study aims to determine the effect of 20 weeks of WBVT on muscle and bone in children with CP. This should lead to improved health and well-being of children with CP. Further, it would open the way to improve the quality of life of a large number of disabled children with other disorders associated with reduced muscle mass.

Interventions

Participantswill perform whole body vibration training (WBVT) four times a week for 20 weeks. Each training session consists of three 3 minute WBVT with 3 minute short breaks between each WBVT. WBVT requires the participant to stand on a vibration plaque that moves rapidly (10-20Hz) up and down over a small distance (up to 10mm) generating vibration stimulus. The vibration causes the muscles in the legs and body to contract.

Study design

Allocation

Non-randomised trial

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

8 Years to 20 Years

Healthy volunteers

Inclusion criteria

Children and adolescents with cerebral palsy (GMFCS II, III and IV) aged between 8 and 20 years. To be included in the study participants must be able to stand on vibration platform and be able to undertake evaluation of the therapy.

Exclusion criteria

Participants will be excluded if: 1) they have a fracture of any type within 8 weeks of enrollment, pregnancy and acute thrombosis, muscle or tendom inflammation, renal stones, discopathy or arthritis. 2) there is history of clinically significant organic disease or findings on physical examination, which in the opinion of the investigator would prevent the patient from completing the study. 3) There is history of using any of the following medications, regardless of dose, for at least 1 month, within 3 months of enrollment: anabolic agents, glucocorticoids (does not include inhaled glucocorticoids) or growth hormone. 4) serum 25-hydroxyvitamin D < 50mmol/L 5) received Botulinium toxin injection into lower limbs within 3 months of enrollment. Participants will not receive Botolinium toxin injection throughout duration of the study.

Outcome results