None listed
Conditions
Brief summary
Prostatitis is the most common urologic pathology in men younger than 50 years and represents 13,8% of urologic office visits .The most frequent form is the chronic abacterial prostatitis or type III prostatitis, according to the National Institutes of Health (NIH) prostatitis classification system, called Chronic Pelvic Pain Syndrome (CPPS) . Lifestyle change still represents the first step of medical therapy in many common pathologies . Several studies have focused the etiology of prostatitis on dietaries habits and some lifestyle activities. However, the potential benefits of a therapeutic regimen based on a strict adhesion to a specific lifestyle and dietary reccomendations have never been investigated. Objectives of the present study are: 1) to review medical literature about risk factors for prostatitis coming from abnormal lifestyle and dietary habits. 2) to prepare a vademecum of lifestyle and diet modifications based on scientific evidences 3) to investigate the incidence of these risk factors in a population of patients coming to our centre complaining of CPPS. 4) to investigate the effectiveness and the compliance to this vademecum associated to the most common therapies actually used for prostatitis like NSAIDs (nimesulide) and phitotherapy (Serenoa repens).
Interventions
1) Nimesulide 100 mg bidaily for one week
2) Serenoa Repens (Saw Palmetto) one 320 mg tablet each day for three months.
Saw palmetto is an extract of the fruit of Serenoa Repens: it is a phytotherapic agent commonly used worldwide for prostatic conditions. Its effectiveness for prostatitis was already showed in many clinical trials.
3) Intervention: modification of lifestyle and diet for three months.
patients belonging the interventional arm are strongly recommended to strictly follow some li
1) Nimesulide 100 mg bidaily for one week 2) Serenoa Repens (Saw Palmetto) one 320 mg tablet each day for three months. Saw palmetto is an extract of the fruit of Serenoa Repens: it is a phytotherapic agent commonly used worldwide for prostatic conditions. Its effectiveness for prostatitis was already showed in many clinical trials. 3) Intervention: modification of lifestyle and diet for three months. patients belonging the interventional arm are strongly recommended to strictly follow some lifestyle rules and dietary recommendations giving them a list prepared by Dr. Luigi Gallo, (MD specialist un urologist) including the following: Modifications of diet: avoidance of alcohol beverages, sodas, spicy foods, pepper, chilli, coffee, artificial sweeteners, tea. Modifications of lifestyle: 1) Walking and practicing relaxing sport activities (swimming, jogging, free exercises). 2) regular sexual activity: a)avoidance of sexual abstinence for more than 4 days b)Do not try to delay ejaculation in both masturbation and intercourse c)Do not practice interrupted coitus as contraceptive method. d)Do not have two ejacultations during the same day 3) Avoidance of sitting position for long time 4) Avoidance of sports that can be traumatic for the prostate (bicycling, motorcycling, horse riding etc.) 5) Avoidance of wearing tight underpants or trousers At second consultation (at the end of 3 months) patients assigned to this group will be invited to refill a questionnaire assessing the grade of acceptance to lifestyle modifications. Only the patients who will correctly follow lifestyle recommendations will be considered for outcome measurements, the others will be excluded.
Sponsors
Studio Urologico Gallo
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1) patients coming to our center with a diagnosis of Category IIIa or IIIb CPPS (with or without presence of leukocytes) 2) age between 20 and 50 years 3) a score of > 1 in pain domain of NIH-CPSI 4) duration of symptoms for more than 3 months 5) presence at clinical history of at least one lifestyle or diet risk factors.
Exclusion criteria
1) diagnosis of a bacterial form of prostatitis (category I and II of NIH) assessed after lower urinary tract localisation studies 2) a previous urinary tract infection within the last year 3) assumption of drugs which could modify lower urinary tract function during the previous three months 4) Severe gastric problems , coagulation problems, renal and/or epatic failure contraindicating assumption of NSAIDs.
Outcome results
None listed