None listed
Conditions
Brief summary
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in Australia. High blood pressure is one of the major modifiable risk factors for the development of CVD. There is a strong association between sodium chloride salt intake and elevated blood pressure. Salt reduction in diets has been shown to reduce blood pressure but salt intakes remain very high in many countries. Recent studies have shown that long term use of a “salt substitute” – potassium chloride, can result in significant reductions in blood pressure. However, there are currently no published studies on the acute effects of potassium chloride on blood pressure. The aim of this research study is to compare the effects of three meals containing different amounts of sodium and potassium salts on blood pressure and blood vessel function.
Interventions
1. Low Sodium [low in sodium (~500mg) and low in Potassium (~500mg)]
2. High Potassium [low in sodium (~500mg) and high in Potassium (~1500mg)]
This study involves comparing the effects of three meals comprising of meat and bread (containing different amounts of sodium and potassium) on brachial and central bloodpressure.
Washout of at least 72 hours between test days.
Measures will be collected every fifteen minutes for three hours postprandially and comparisons will be made between the contr
1. Low Sodium [low in sodium (~500mg) and low in Potassium (~500mg)] 2. High Potassium [low in sodium (~500mg) and high in Potassium (~1500mg)] This study involves comparing the effects of three meals comprising of meat and bread (containing different amounts of sodium and potassium) on brachial and central bloodpressure. Washout of at least 72 hours between test days. Measures will be collected every fifteen minutes for three hours postprandially and comparisons will be made between the control and intervention meals for their effects on blood pressure and measures of blood vessel function.
Sponsors
University of Tasmania
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Age: 30 - 70 years Brachial blood pressure: systolic <150 mmHg; diastolic <95 mmHg No history of renal disease No diabetes, liver disease or other heart conditions
Exclusion criteria
Have gluten intolerance Do not eat red meat Have had recent changes in blood pressure medication Are taking medications that may interact with potassium e.g. ACE-Inhibitors
Outcome results
None listed