Expression of molecules that detect the presence of fat in the small intestine.

Identification and quantification of the fatty acid sensing molecules, CD36, GPR119, GPR120, and GPR 40 in the duodenum of lean and obese humans.

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12611000390987

Enrollment

Registered

2011-04-14

Start date

2011-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of the study is to identify, and quantify, the expression of fatty acid sensing molecules, including CD36, GPR119, GPR120 and GPR40, in human duodenal biopsies.

Interventions

Participants will undergo endoscopy (as scheduled for clinical reasons). Small intestinal biopsies will be obtained. The duration of the trial will be approximately 1 hour.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

Patients aged 18-75 years, scheduled to undergo surveillance endoscopy at the Royal Adelaide Hospital.

Exclusion criteria

-diffuse mucosal disease involving the upper gastrointestinal tract, including Crohn's disease, coeliac disease, or ischaemic changes, evident either macroscopically or on histopathological examination of mucosal biopsies, when the latter is clinically indicated. -gastrointestinal symptoms -ongoing anticoagulation or bleeding disorder, or use of anticoagulant drugs (e.g. aspirin, clopidogrel)

Outcome results