Does the anaesthetic drug propofol affect the blood levels of the endogenous cannabis-like substance anandamide?

Effect of propofol on the peri-operative plasma level of the endogenous cannabinoid anandamide in patients undergoing minor elective surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000361909

Enrollment

Registered

2011-04-07

Start date

2011-03-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Anandamide is a body-own (endogenous) cannabis-like substance that is significantly involved in our response to stress, but also affects mood and has anti-nausea effects. In the proposed project we will investigate the effect of the drugs propofol and sevoflurane (two of the most commonly used anaesthetic agents) on the blood concentration of the cannabis-like substance anandamide in 30 patients having an operation at Royal Perth Hospital. In this trial, patients (15 each) will either receive an anaesthetic with propofol or with sevoflurane and we will measure the blood levels of anandamide by drawing blood (2x5ml) from a venous cannula anyway used to give the anaesthetic at 5 time points. Results of this project will help us to understand significant positive side effects of propofol, such as its anti-nausea properties.

Interventions

Maintenance of anaesthesia with intravenous propofol (target controlled infusion as clinically required: 4-6 mcg/ml)/fentanyl (as clinically required)

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Diagnosis

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

patients scheduled for minor non-emergency surgery

Exclusion criteria

Age < 18 yrs and > 65 yrs, ASA physical status > 2 (= significant comorbidity), history of chronic pain, a contraindication for any of the used drugs, and the incapacity to consent.

Outcome results