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4D Positron Emission Tomography/Computerised Tomography (PET/CT) in Liver Surgical Planning

A pilot study to investigate the impact of contrast enhanced CT and Gated PET in patients with colorectal liver metastases.

Status
Withdrawn
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12611000358943
Enrollment
20
Registered
2011-04-06
Start date
2011-06-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The hypothesis of this study is that an enhanced PET/CT scanning protocol using new technology to monitor patient's breathing will detect disease that was not seen by any other scanning technique. The intervention being tested is the new respiratory scanning technology. This technology is able to create a video of a patient breathing rather that a snap shot to correct any blurring caused by normal breathing.

Interventions

A standard whole body PET/CT scan will be performed first. This involves a patient lying on a scanning table for around 20 mins while breathing normally. The patient will recieve CT and a PET scan from the base of the brain to thighs. Then at the conclusion of the whole body PET/CT scan the patient will be administered with IV contrast and asked to hold their breath while a high quality CT scan of the liver is acquired taking about 30 seconds. Once the contrast CT scan has concluded the patie

A standard whole body PET/CT scan will be performed first. This involves a patient lying on a scanning table for around 20 mins while breathing normally. The patient will recieve CT and a PET scan from the base of the brain to thighs. Then at the conclusion of the whole body PET/CT scan the patient will be administered with IV contrast and asked to hold their breath while a high quality CT scan of the liver is acquired taking about 30 seconds. Once the contrast CT scan has concluded the patient will be instructed to breath normally again and a 10 minute gated PET scan of the liver will be acquired.

Sponsors

Peter MacCallum Cancer Centre
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

Either histologically or clinically proven colorectal cancer with liver metastases for resection.

Exclusion criteria

1. Lack of patient compliance for additional scan time requirement 2. Breathing trace technically unsatisfactory for respiratory gating. 3. Allergy to CT radiographic contrast

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026