Tyrosine supplementation in preventing the cognitive effects of psychosocial stress

Tyrosine supplementation versus placebo in preventing the cognitive effects of psychosocial stress in healthy adults

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000357954

Enrollment

Registered

2011-04-06

Start date

2011-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to evaluate the effects of the administration of the natural amino acid, tyrosine, compared with that of a placebo on the cognitive functioning of healthy adult volunteers subjected to an acute psychosocial stress event. This is based on the hypothesis that pre-test administration with tyrosine will prevent or reduce the negative impact of psychosocial stress on a broad range of cognitive tasks through its effect on neurotransmitter functioning

Interventions

Once off administration of an oral solution containing either the natural amino acid tyrosine (at a dose of either 100mg/kg or 200mg/kg) or a placebo to healthy adult (male and female) volunteers, two hours prior to exposure to psychosocial stressor (Trier Social Stress Test). To be administered randomly and in a blinded manner

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy adult volunteers

Exclusion criteria

Past or present mental illness Family history of mental illness Any medication or illicit substance use Pregnant

Outcome results