Does lactoferrin improve survival free from morbidity in very low birth weight infants? Lactoferrin Infant Feeding Trial: a randomised controlled trial

Conditions

None listed

Brief summary

A two arm randomised controlled trial in more than 1500 preterm babies less than 1500 grams to compare standard feeding regimens versus adding BLF to feeds on the incidence of death and major disability in VLBW infants.

Tarnow-Mordi WO, Abdel-Latif ME, Martin A, Pammi M, Robledo K, Manzoni P, Osborn D, Lui K, Keech A, Hague W, Ghadge A, Travadi J, Brown R, Darlow BA, Liley H, Pritchard M, Kochar A, Isaacs D, Gordon A, Askie L, Cruz M, Schindler T, Dixon K, Deshpande G, Tracy M, Schofield D, Austin N, Sinn J, Simes RJ, LIFT collaborators.

2020-05-1241 citations

10.1016/s2352-4642(20)30093-6

Enteral lactoferrin does not reduce late‐onset infection in very preterm infants

Aishath Rizma Moosa, Yifei Wang, Elaine M. Boyle

Acta Paediatrica2019-11-21

10.1111/apa.15073

Protocol for the Lactoferrin Infant Feeding Trial (LIFT): a randomised trial of adding lactoferrin to the feeds of very-low birthweight babies prior to hospital discharge

Andrew Martin, Alpana Ghadge, Paolo Manzoni, Kei Lui, Rebecca T. Brown et al. (6 authors)

BMJ Open2018-10-0112 citations

10.1136/bmjopen-2018-023044

Interventions

Bovine Lactoferrin (BLF): Dosage - 200 mg/kg/day added to breast milk or formula, once daily. Study intervention is administered until 34 weeks corrected gestation or for 2 weeks, whichever is longer, or until discharge home, if earlier.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

0 to 7 Days

Healthy volunteers

No

Inclusion criteria

Babies are eligible if (a) <1500 g birth weight (b) less than or equal to 7 days old and expected to survive and (c) parent gives written informed consent.

Exclusion criteria

Babies with severe congenital anomalies which are likely to cause death are not eligible

Outcome results