None listed
Conditions
Brief summary
The primary purpose of the study is to investigate the effect of critical illness on blood flow to the gastrointestinal tract during feeding and the absorption of sugar in older patients. We hypothesize that the change in blood flow to the gastrointestinal tract during feeding and the absorption of sugar in ICU patients will be less than that of healthy volunteers. This may indicate a possible mechanism for malabsorption during critical illness or alternatively, when to start feeding critically ill patients via the gastrointestinal route.
Interventions
A nasoduodenal feeding tube will be inserted through the nose and positioned in the proximal duodenum using the Cortrak device. Between t = 60 and 120 min infusion of 0.9% saline into the duodenum. At t = 120 min, an intraduodenal glucose infusion will begin (32 g glucose together with 3 g 3-oxy-methyl-D-glucose (3-OMG) in water to a total volume of 120mL, and infused over 60 minutes ~ 2 kcal/min). Participants will undergo this intervention once, after consent has been granted by the next of ki
A nasoduodenal feeding tube will be inserted through the nose and positioned in the proximal duodenum using the Cortrak device. Between t = 60 and 120 min infusion of 0.9% saline into the duodenum. At t = 120 min, an intraduodenal glucose infusion will begin (32 g glucose together with 3 g 3-oxy-methyl-D-glucose (3-OMG) in water to a total volume of 120mL, and infused over 60 minutes ~ 2 kcal/min). Participants will undergo this intervention once, after consent has been granted by the next of kin.
Sponsors
Jennifer Sim
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Critically ill mechanically ventilated patients > 65 years of age who are receiving, or suitable to receive, enteral nutrition Healthy volunteers >65 years of age
Exclusion criteria
Any contraindication to enteral feeding, previous surgery to the oesophagus, stomach or duodenum, any gastrointestinal surgery during their current hospital admission, patients with known Diabetes mellitus, patients receiving antihypertensive medications, patients receiving exogenous catecholamine(noradrenaline and adrenaline) > 30 ug/min, Body Mass Index >32 kg/m2, Patients requiring a mean arterial blood pressure > 80 mmHg
Outcome results
None listed