Effects of acute ketamine administration on mental representations of the body in healthy participants.

Status

Withdrawn

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000197932

Enrollment

Registered

2011-02-21

Start date

2011-08-04

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To determine whether or not acute ketamine administration produces schizophrenic-like changes in the way one's own body is represented mentally.

Interventions

0.16 mg/kg I.V. dose of ketamine administered over an hour.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy participants

Exclusion criteria

1. Pregnancy or currently breastfeeding 2. Neurological disorders or known seizure risk 3. History of loss of consciousness for over 5 mins 4. Current diagnosis or treatment for a mental illness 5. Past or current treatment for substance use disorder 6. Significant risk of psychoses (previous history of psychosis or first-degree relative diagnosed with schizophrenia/schizophrenia-spectrum disorders) 7. Presence or history of a kinetic disorder 8. Presence or history of hypertension 9. Presence or history of hepatic insufficiency 10. Presence of renal insufficiency 11. Presence or history of cardiovascular disorder 12. Significant risk of suicide 13. Known hypersensitivity to ketamine 14. Receiving any systematic prescription medication (excluding oral contraceptive pill)

Outcome results