Corneal Collagen Cross-linking (CXL) as an adjunct in the treatment of Microbial Keratitis

In patients with microbial keratitis, is conventional treatment plus corneal collagen cross-linking (CXL) more effective than conventional treatment alone in terms of time to healing, visual results, and secondary interventions required?

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000189921

Enrollment

298

Registered

2011-02-17

Start date

2011-08-22

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Microbial keratitis is a significant cause of ocular morbidity and visual loss, as well as a significant health cost to the community. Ultraviolet light is known to be microbicidal. We think it is likely that the proposed treatment will lead to quicker recovery from this serious eye infection and better visual outcomes.

Interventions

riboflavin 0.1% indextran solution is applied to the cornea every 2 minutes for 30 minutes, and then ultraviolet A light at 365nm and 3 watts/cm2 exposure is applied for a further 30 minutes

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

presumed or confirmed microbial keratitis of moderate severity or worse

Exclusion criteria

Pregnancy impending or actual corneal perforation

Outcome results