Efficacy of continuous preperitoneal infusion of ropivacaine in laparoscopic colorectal surgery

Efficacy of postoperative continuous preperitoneal infusion of 0.5% ropivacaine at 4ml/hr after laparoscopic colorectal surgery compared to intravenous patient controlled postoperative analgesia

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000183987

Enrollment

Registered

2011-02-16

Start date

2011-06-08

Completion date

2013-04-09

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This controlled double blinded randomized clinical study intend to investigate postoperative analgesia and bowel recovery thus overall recovery efficacy of continuous preperitoenal infusion of 0.5% ropivacaine compared to intravenous opioid based patient controlled postoeprative analgesia. The main hypothesis of this study is that analgesic method using local anesthetic will provide equivalent or better analgesia with prompt bowel recovery.

Interventions

Intervention consists preperitoneal placement of catheter with multiple side-holes to continuously release 0.5%ropivacaine at 4ml/hr for postoperative 72hours. This placement will be conducted by an experienced attending surgeon. Intervention with 0.5% ropivacaine (local anesthetics) continuous infusion at 4ml/hr

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

ASA PS 2-3 patients undertaking laparoscopic colorectal surgery

Exclusion criteria

patients with previous opioid analgesic medication allergic to local anesthetics or opioid coagulopathy or hemostatic abnormalities neurologic disorder / mental disorder obesity BMI > 30

Outcome results