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A single centre, prospective, non-randomised, non-comparative interventional case series investigating the efficacy of direct corneal neurotization using supraorbital and supratrochlear nerves in patients with anaesthetic cornea.

Direct corneal neurotization of anaesthetic cornea. Non comparative study to evaluate the efficacy of direct corneal neurotization using supraorbital and supratrochlear nerves in patients with anaesthetic cornea.

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12611000179932
Enrollment
5
Registered
2011-02-15
Start date
2011-02-15
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study is been carried out to investigate if transplanting the nerve from the opposite side to replace the damaged one will help restore sensation to your numb cornea. If procedure is successful, it will restore sensation to your cornea and help prevent the cornea from developing ulcers. This procedure has previously been shown to be successful in restoring sensation to numb corneas.

Interventions

To evaluate the efficacy of direct corneal neurotization using supraorbital and supratrochlear nerves in patients with anaesthetic cornea. Through a bicoronal incision, the supratrochlear and supraorbital nerves will be identified and carefully dissected under high magnification. The nerve branches will then be tunnelled over the nasal bridge to a small incision along the lid crease of the upper lid of the contralateral anaesthetic eye. Under the operating microscope, the distal nerve branches

To evaluate the efficacy of direct corneal neurotization using supraorbital and supratrochlear nerves in patients with anaesthetic cornea. Through a bicoronal incision, the supratrochlear and supraorbital nerves will be identified and carefully dissected under high magnification. The nerve branches will then be tunnelled over the nasal bridge to a small incision along the lid crease of the upper lid of the contralateral anaesthetic eye. Under the operating microscope, the distal nerve branches will be retrieved with a fine hemostat inserted through a tiny incision under the upper lid. The eye will then be directed downward using a superior rectus tendon traction suture. An incision through the superior bulbar conjunctiva 7mm behind the superonasal position of the corneal limbus will be made. In the potential space between where the sclera and Tenon’s capsule are juxtaposed to the anatomical corneal limbus, a tunnel will be created by blunt dissection using curved scissors around the circumference of the corneal limbus both temporally and nasally to the points of planned insertion of the prepared nerves. The distal nerve branches will be passed into the prepared perilimbal space, fanned and sutured into place in the conjunctival sac next to the corneal limbus with 10-0 monofilament nylon sutures under direct high magnification. The overall surgery time will be approximately 45 minutes.

Sponsors

Royal Adelaide Hospital
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No

Inclusion criteria

All patients with global anaesthetic corneas as confirmed by clinical examination and esthesiometry.

Exclusion criteria

Patients with transient causes of neurotrophic keratopathy e.g. Corneal anesthesia post LASIK, radiotherapy induced neurotrophic keratopathy Patients with condition that may affect healing or not amendable to neurotization e.g. focal anaesthetic cornea, band keratopathy, conjunctival disease, previous corneal surgery, significant subepithelial stromal scar Patients that intervention may preclude future sight preserving operation to the eye e.g. glaucoma which may require filtration surgery Patients with systemic illness that precludes operation

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026