None listed
Conditions
Brief summary
Participants come for one practice visit where they go through the screening questions and provide informed consent. They also practice on all cognitive and mood tasks they will be doing on their subsequent testing sessions. Participants come for 3 testing sessions at least 1 week apart. At each testing session, they first complete baseline 'mood, cognitive, mood' assessments and doppler ultrasound followed by treatment administration. They complete 'mood, cognitive mood' assessment at 40mins and 120mins post dose and doppler at 90mins post dose
Interventions
Participants each consume one dose of each of the 3 treatments: coffee (6g), coffee extract (540mg), placebo at least 1 week apart.
All treatments are powder form and mixed with water (with milk/saccharin as desired)
Sponsors
Nestec
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
*Age 50 and over *Healthy (i.e. absence of all exclusion criteria) older male and female adults *Light to moderate coffee drinkers (i.e. with caffeine) *Drink no more than 8 cups of coffee per week *Participants must abstain from caffeine-containing foods/beverages and alcohol for 24 hours prior to the training session and each testing session. *Written informed consent obtained
Exclusion criteria
*Existing or pre-existing physical or neurological conditions *History of psychiatric, cardiac, endocrine, gastrointestinal, or bleeding disorders *Clinically high blood pressure *Under treatment with spironolactone-like anti-diuretics, aldosteron-receptors antagonists or angiotensin II- antagonists *Hearing impairment *Psychoactive medications *History of substance abuse *Smoker *Food allergies *Potassium reduced diet *Score <24 on the Mini-Mental State Exam *Currently participating or having participated in another clinical trial during the last 2 months prior to the beginning of this study
Outcome results
None listed