Comparison of hemodynamic parameters of isoflurane and sevoflurane during lowflow controlled anesthesia

Comparison of hemodynamic parameters between low flow Isoflurane and low flow Sevoflurane anesthesia during controlled ventilation with Laryngeal Mask Airway

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000050954

Enrollment

Registered

2011-01-14

Start date

2011-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Laryngeal Mask Airway(LMA) is a good device for airway management which is used routinly in operating room nowadays.Low flow anesthesia is almost a new concept in maintenance of anesthesia which leads to better control of airway temperature and humidity with stable hemodynamic. Previous studies showed that we can use isoflurane with controlled low flow anesthesia during operation. Sevoflurane is a new anesthetic which has some priorities to other anesthetics. But there are some concerns about its use during contooled low flow anesthesia with LMA. 80 patients will be enrolled in this study. Patients will be randomized to two 40 patient groups. In one group anesthesia will be maintained with isoflurane and in the other group will be maintained by sevoflurane. All patients will be ventilated through LMA with low flow anesthesia. Hemodynamic Parameters will be noted during anestheia for each person.

Interventions

maintenance of low flow Anestheia with volume controlled ventilation through Laryngeal Mask Airway(LMA)with sevoflurane(Inhaled anesthetic) with 2-2.5% in initial phase(10 minutes) and after that maintained on 3-3.5% till we reach near the time of ending operation., at first we set fresh gas flow at 6 lit/min and after that the fresh gas flow decreases to 1lit/min during 10-15 minutes. hemodynamic parameters will be monitored.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

Adult patients(20-60) y.o with ASA physical status 1-2 who are candidated for elective surgery

Exclusion criteria

difficult airway, history of malignant hyperthermia,alcoholism,uncomponsated diabetes mellitus, long duration of fasting,heavy smoking, renal failure and impared co2 absorbant.

Outcome results