A study of proteins involved in the inflammation and pain associated with arthritis of the knee.

The relationship between clinical phenotype and kinin bioregulation in arthritis

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12611000048987

Enrollment

Registered

2011-01-13

Start date

2011-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A study of proteins involved in the inflammation and pain associated with arthritis of the knee The study involves inviting people with a diagnosis of arthritis of the knee to participate in the study. The treatment for their arthritis will not be altered in any way. Participants will be asked to attend a single appointment, which will take about 2 hours and the following will occur: Questions about their health and specifically their arthritis and about any medications they are taking. This will be followed by a physical examination by the doctor (including weight, height, abdominal and waist circumference, BP) Questionnaires about pain, and difficulties/disability caused by the arthritis and associated pain. The knee joint will be examined by a doctor and undergo an ultrasound examination of the knee. The fluid in the knee will be withdrawn through a needle.

Interventions

Aspiration of synovial fluid, by insertion of a needle into the inflammed joint and removal of fluid. Collection of serum through phlebotomy Collelction of urine All samples are collected at the same time. The observational study is cross sectional, with each subject having one visit at one point in time.

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

OA of the knee based on ACR clinical criteria Active gout of the knee RA meeting ACR criteria PsA meeting CASPAR criteria

Exclusion criteria

Contraindication or unwillingness to undergo an US scan Contraindication or unwillingness to undergo arthrocentesis (Including an INR> 2) Diagnosis of septic arthritis, Paget’s disease, articular fracture, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, primary osteochondrosis Injury to the study knee within 6 months of the study start knee joint replacement (partial or total); osteotomy of the studied joint; with arthroscopy of the studied joint made within 1 year of the study start With an intra articular injection of steroids made within 4 weeks and/or intra articular injection of radionuclide made with 3 months prior to study entry

Outcome results