The Effects of Delta 9-tetrahydrocannabinol (THC) on Driving Performance, Cognition, Fatigue and Stress.

The Effects of Delta 9-tetrahydrocannabinol (THC) on Driving Performance, Cognition, Fatigue and Stress on Healthy Volunteers.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12611000030976

Enrollment

Registered

2011-01-10

Start date

2010-02-03

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to examine the effect of THC (active component in cannabis) on driving performance along with various measures of cognition and decision-making, fatigue, vigilance (attention) and stress during both the acute and residual phases of cannabis consumption. A double-blind, placebo-controlled, counterbalanced cross-over design means that 20 healthy participants will will attend 2 experimental conditions and smoke either 2* THC cigarettes or 2* Placebo cigarettes at each testing session.

Interventions

The level of THC administered will be 2x 3.2% THC cigarettes over a period of 12-15 minutes (16 puffs or less in total). This will be a one-off intervention undertaken during one of two testing conditions, spaced exactly 1 week apart.

Eligibility

Sex/Gender

All

Age

21 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

Experienced cannabis smoker Holder of full Driver's License

Exclusion criteria

History of substance abuse or dependence for any drug; Known allergic reaction to cannabis in the past ; Chronic Cannabis user; Wears glasses or spectacles to read/use a computer (contact lenses okay); History of psychiatric illnesses, especially Anxiety/Depression, Schizophrenia, Bipolar Disorder &/or Psychosis; Pregnant, lactating, or potentially pregnant; History of the following medical conditions: Cardiovascular conditions, Respiratory conditions, Endocrine conditions, Gastrointestinal conditions, Bleeding disorders, Neurological disorders, Liver or kidney conditions, Brain injury or Traumatic Head Injury or prolonged periods of unconsciousness; Currently taking prescription medication (other than a contraceptive pill)

Outcome results