Day 3 versus day 5 embryo transfer in high-responding women undergoing in vitro fertilization: a randomized controlled trial

Day 3 versus day 5 embryo transfer in high-responding women on pregnancy outcomes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000028909

Enrollment

200

Registered

2011-01-10

Start date

2008-09-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The objective of this trial is to test the hypothesis that delaying embryo transfer to blastocyst stage may increase the probability of pregnancy in high responders undergoing their first ICSI cycles using the long agonist protocol.

Interventions

Embyro transfer on Day 5 post oocyte pick-up and intracytoplasmic sperm injection (i.e. fertilization). Number of embryos will depend on number available on day of transfer but the target for this group is 2 embryos per transfer.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* women’s age <=35 years, with regular cycles (24 to 35 days) * day 3 follicle stimulating hormone (FSH) <9.5 IU/L * antral follicle count (AFC) >6 * E2 levels >3,000 pg/mL & endometrial thickness >=8 mm on the day of hCG administration * at least four grade one embryos (i.e. regular symmetrical blastomeres with no fragmentation) on day 3 after retrieval

Exclusion criteria

* women's age >35 years * <4 grade one embryos on day 3 after retrieval

Outcome results