Regional delivery of prophylactic antibiotics in total knee arthroplasty via an intraosseous route A tissue penetration study

Total Knee Arthroplasty patients given intraosseous or systemic prophylactic antibiotics and tissue concentrations measured

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12611000001998

Enrollment

Registered

2011-01-04

Start date

2010-04-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of this study is to assess the feasibility of the intraosseous route in providing higher local tissue concentrations of prophylactic antibiotics in knee replacement surgery.

Interventions

Immediately following tourniquet inflation Group 1 would then receive a single 1g dose of cefazolin via an intraosseous cannula into the proximal tibia. The cefazolin would be administered in 200ml of saline solution.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Healthy volunteers

Inclusion criteria

Total Knee Replacement patients Osteoarthritis Body Mass Index (BMI)<30

Exclusion criteria

Active infection Impaired renal function Allergiy to antibiotic

Outcome results