Repeat prostate evaluation and therapy pilot study in patients undergoing high dose rate brachytherapy for prostate cancer

A pilot study to evaluate tolerance, safety and efficacy of repeated prostate biopsy in patients undergoing high dose rate brachytherapy for prostate cancer

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610001076066

Acronym

RePEAT Pilot

Enrollment

Registered

2010-12-07

Start date

2010-11-16

Completion date

2014-01-21

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

a preliminary study of the ability to obtain tissue before and after radiation therapy (using brachytherapy) for the purpose of studying the molecular and cellular response of the cancer.

Interventions

Repeated prostate biopsies are to be obtained from malignant areas identified on previous transrectal ultrasound biopsy. These will be prior to the first high dose rate (HDR) brachytherapy fractions and at various durations prior to the second HDR dose, and again approximately 30 minutes after that dose (i.e. up to 5 biopsies in total).

Study design

Allocation

Non-randomised trial

Primary purpose

Diagnosis

Eligibility

Sex/Gender

Male

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

Patients undergoing high dose rate brachytherapy for prostate cancer

Exclusion criteria

previous transurethral resection of prostate (TURP), anticoagulation, previous sepsis from prostate biopsy

Outcome results