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Cardiac function and cerebral blood flow in the beachchair surgical patient.

The effect of vasopressor therapy with phenylepherine infusion versus a placebo saline infusion on cardiac function and cerebral blood flow in the beachchair surgical patient.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12610001075077
Enrollment
34
Registered
2010-12-07
Start date
2010-06-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

During shoulder surgery patients are commonly positioned into an upright sitting position for optimal access to the shoulder joint. In some patients blood pressure may decrease and a concern of the anaesthetist is whether sufficient blood reaches the brain during such surgery. Even though this can be routinely treated with cardiac drugs, the exact effect of this treatment on the brain is unknown. This study plans to investigate the changes in cardiac function and flow to the brain when patients are anaesthetised and placed upright. The surgery will be performed using the anaesthetic technique that we use for the majority of the surgeon’s cases. The patient will receive a nerve block that will anaesthetise the arm receiving surgery. This will be combined with a general anaesthetic. Special monitoring of the heart and blood flow using sound waves, and brain function using reflected light waves will be used. These techniques are both non-invasive and present no harm to the patient. The study will investigate whether the administration of medication to gently increase blood pressure has an effect on hypotension and blood flow to the brain. In addition postoperative cognitive recovery will be assessed via a questionaire. By agreeing to the study patients will give us permission to make these extra measurements during anaesthesia, in order to understand whether we are protecting the brain during surgery.

Interventions

This study will investigate the effects of vasopressor therapy on cerebral blood flow and oxygenation, in the beach chair position during shoulder surgery. Following interscalene brachial plexus anaesthesia with 20-20 ml ropivicaine 0.75%, general anaesthesia will be induced with propofol 50-200mg and maintained on sevoflurane 2-3%. Phenylephrine infusion 0.15 - 0.5 microgram/kg/min titrated to increase mean arterial pressure by 20 % versus saline infusion. Infusion is maintained whilst patient

This study will investigate the effects of vasopressor therapy on cerebral blood flow and oxygenation, in the beach chair position during shoulder surgery. Following interscalene brachial plexus anaesthesia with 20-20 ml ropivicaine 0.75%, general anaesthesia will be induced with propofol 50-200mg and maintained on sevoflurane 2-3%. Phenylephrine infusion 0.15 - 0.5 microgram/kg/min titrated to increase mean arterial pressure by 20 % versus saline infusion. Infusion is maintained whilst patient placed into beachchair position for surgery. The duration of intervention is 1 hour.

Sponsors

The Avenue Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

>18 years of age Shoulder surgery suitable for beach chair position Able to provide informed consent

Exclusion criteria

Previous cerebrovascular event Current cardiac disease including pacemaker Cerebrovascular disease Significant cardiac or respiratory impairment Contraindications to interscalene block Inadequate understanding of English Body Mass Index (BMI) > 35

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026