Does Tranexamic Acid reduce transfusion rate in Total Hip Replacements?

In patients undergoing primary total hip replacements for osteoarthritis or avascular necrosis (AVN), does the use of tranexamic acid just prior to surgery reduce the transfusion rate and units transfused when compared to a placebo?

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12610001065088

Enrollment

Registered

2010-12-03

Start date

2011-08-15

Completion date

2016-12-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The aim of the study is to reduce the blood transfusion rate after a total hip replacement by giving a medication (tranexamic acid) through the vein just before the operation starts. This medication has been shown to be safe in most patients in similar studies overseas and is occasionly used in situations of extreme blood loss in New Zealand currently. It has been shown to reduce blood loss in routine total hip replacements in previous research performed overseas however it's effect on transfusion has not been assesed as a primary outcome. It is not routinely used in New Zealand currently

Interventions

1g Intravenous Tranexamic acid infused ove 10 minutes just prior to surgery.

Study design

Allocation

Randomised controlled trial

Primary purpose

Prevention

Masking

Blinded (masking used) (Caregiver)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Primary total hip replacement Diagnosis of osteoarthritis or avascular necrosis

Exclusion criteria

Contraindications for tranexamic acid Bleeding disorder Use of Warfarin or Clexane or clopidogrel History of thromboembolic disorder

Outcome results