None listed
Conditions
Interventions
This study will compare the use of a commonly used sedative drug – propofol, used alone or in combination with another drug that has sedative and pain relieving properties called ketamine. The idea is that using a combination of the two drugs together will result in lower doses of each being used if they were to be used independent of one another.
1) Initial Dose in ml equates to 0.5mg kg Propofol alone or 0.25mg/kg Ketamine and propofol in combination
2) Subsequent doses are at half those amoun
This study will compare the use of a commonly used sedative drug – propofol, used alone or in combination with another drug that has sedative and pain relieving properties called ketamine. The idea is that using a combination of the two drugs together will result in lower doses of each being used if they were to be used independent of one another. 1) Initial Dose in ml equates to 0.5mg kg Propofol alone or 0.25mg/kg Ketamine and propofol in combination 2) Subsequent doses are at half those amounts minutely prn 3) The mode of administration is Intravenous injection.
Sponsors
QE II Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Need for emergency department procedural sedation
Exclusion criteria
Inability to provide consent, age <18yrs, pregnancy, soy or egg allergy, Glasgow Coma Scale<15, hypotension, severe systemic disease (American Society Anesthesiologists class IV or greater), uncontrolled hypertension (Blood Pressure>160/90), patients with known Abdominal Aortic Aneurysm or symptomatic Ischaemic Heart Disease.
Outcome results
None listed