None listed
Conditions
Brief summary
A recent discovery in our laboratory demonstrated that in comparison with lean subjects, the alimentary canal (oral and gastrointestinal tract) response to fats and fatty acids in foods was attenuated in overweight and obese human subjects. This data supports evidence that overweight and obese individuals consume excess dietary fat. There are two possibilities for these findings, first, that consumption of a high-fat diet induces environmental adaptive changes in the body’s sensitivity to fat, or, second, that genetic predisposition determines an individual’s fat sensitivity. Using both monozygous and dizygous twin pairs; we will estimate the magnitude of fat sensitivity heritability and its links to obesity.
Interventions
6-week dietary intervention using a diet containing 25% energy from fat. Core foods for the diet will be delivered to the subjects. Such foods include: low fat milk and yoghurts (including frozen yoghurt), oils, low fat bran muffins and lean meats. These foods will be incorporated into the daily diet of the subjects and so they will consume these foods when they would normally have their meals and snacks. These foods will replace the higher fat alternatives in the subjects' diets.
Sponsors
Deakin University
Study design
Allocation
Non-randomised trial
Primary purpose
Diagnosis
Eligibility
Sex/Gender
All
Age
18 Years to 39 Years
Healthy volunteers
Yes
Inclusion criteria
Male and female mono- and di-zygotic twin pairs, aged between 18-39years, English speaking and BMI between 18-35.
Exclusion criteria
Individuals aged under 18 years or above 39 years, BMI under 18 or over 35, non-English speaking.
Outcome results
None listed