None listed
Conditions
Brief summary
This project aims to investigate if chewing gum will increase circulating nitrite and nitric oxide and if these effects are associated with cognitive and vascular benefits.
Interventions
A randomized controlled crossover-design trial will be conducted to investigate the acute effects of chewing gum on metabolism of nitrogen oxides, as well as neurocognitive performance outcome measures and endothelial function.
Each participant will complete 2 visits in random order with a minimum of one week washout between each visit. Prior to each visit participants will be asked to consume a standard meal for dinner. For each visit participants will attend the School of Medicine and Pharma
A randomized controlled crossover-design trial will be conducted to investigate the acute effects of chewing gum on metabolism of nitrogen oxides, as well as neurocognitive performance outcome measures and endothelial function. Each participant will complete 2 visits in random order with a minimum of one week washout between each visit. Prior to each visit participants will be asked to consume a standard meal for dinner. For each visit participants will attend the School of Medicine and Pharmacology Research Unit at Royal Perth Hospital in the morning after standard low nitrate breakfast. They will be randomly allocated to: 1. No chewing 2. Chewing Participants will consume a standardized lunch containing a fixed level of nitrate derived from spinach. They will begin chewing gum 30 minutes after lunch and continue chewing for 2 hours. A fruit-flavoured, sugar-free chewing gum will be used.
Sponsors
University of Western Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy men and women aged 20 to 70 years
Exclusion criteria
1.Current or recent (<12 months) smoking 2.Body mass index < 18 or > 35 kg/m2, 3.History of cardiovascular or peripheral vascular disease, 4.A systolic blood pressure below 100 or above 160 mmHg 5.A diastolic blood pressure below 50 or above 100 mmHg 6.Diagnosed diabetes, and non-diabetic individuals with fasting plasma glucose concentrations greater than or equal to 5.5 mmol/L, 7.A psychiatric illness, 8.Other major illnesses such as cancer, 9.Current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight), 10.Reported lactating, pregnant or wishing to become pregnant during the study, 11.Alcohol intake > 210 g per wk for women and > 280 g per wk for men, and 12.Inability or unwillingness to consume foods/beverages provided. 13.Unwillingness to stop the use of supplements 24 hours prior to the testing day. 14.Have any health conditions that would affect food metabolism including the following: food allergies, kidney disease, liver disease and/or gastrointestinal diseases (e.g Irritable bowel syndrome, celiac disease, peptic ulcers) 15.Unable or unwilling to chew gum for 2 hours 16.Unwilling to give up the use of mouth wash while partaking in the study
Outcome results
None listed