None listed
Conditions
Brief summary
Patients with primary open angle glaucoma or ocular hypertensio will be treated with fixed combinations of prostaglandin analogues plus beta blocker. They will be follow for 60 days. Intraocular pressure will be compared. Comparisons beteween groups and with baseline.
Interventions
Patients will use fixed combinations of prostaglandin analogues plus topical beta blockers available on market during 60 days. Patients will be divided in three groups. Each group will recieve one drug. Intraocular pressure will be compared.
If using drugs prior to study, a washout period of 30 days will be necessary.
Half of patients will receive the drug at mornig (8 a.m.) and half at night (8 p.m.). After 30 days they will change the time to use the drug (crossover regarding the instillation
Patients will use fixed combinations of prostaglandin analogues plus topical beta blockers available on market during 60 days. Patients will be divided in three groups. Each group will recieve one drug. Intraocular pressure will be compared. If using drugs prior to study, a washout period of 30 days will be necessary. Half of patients will receive the drug at mornig (8 a.m.) and half at night (8 p.m.). After 30 days they will change the time to use the drug (crossover regarding the instillation time), without washout between these change. The drugs are: Xalacom (latanoprost 0.005%/timolol 0.5%) eye drop once day; Ganfort (bimatoprost 0.03%/timolol 0.5%) eye drop once day; and Duotrav (travoprost 0.004%/timolol 0.5%) eye drop once day.
Sponsors
Enyr Saran Arcieri
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Intra ocular pressure over 21 MMHG
Exclusion criteria
Pregnancy
Outcome results
None listed